Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.56 |
| ▸ | BCL2 | P10415 | 6/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | UQCRB | P14927 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5428199 | 0.88 | NR1I2 (0.54) | CHRM1SERPINE1LMNANR1I2UQCRB | |
| SCHEMBL5419821 | 0.88 | SERPINE1 (0.51) | CHRM1BCL2BCL2L1MCL1SERPINE1 | |
| SCHEMBL3429738 | 0.79 | CHRM1 (0.65) | CHRM1LMNA | |
| SCHEMBL1606606 | 0.77 | LMNA (0.80) | CHRM1LMNA | |
| SCHEMBL2487513 | 0.77 | LMNA (0.84) | CHRM1LMNA | |
| SCHEMBL13621801 | 0.75 | LMNA (0.68) | CHRM1LMNA | |
| SCHEMBL28222415 | 0.75 | LMNA (0.68) | CHRM1LMNA | |
| SCHEMBL5430473 | 0.75 | NR1I2 (0.51) | SERPINE1LMNANR1I2UQCRB | |
| SCHEMBL5990098 | 0.75 | L3MBTL1 (0.59) | BCL2BCL2L1MCL1SERPINE1LMNA | |
| SCHEMBL5421083 | 0.74 | SERPINE1 (0.81) | SERPINE1NR1I2UQCRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | claimed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | claimed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | claimed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | claimed |
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | disclosed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | IDO2, IDO1, INMT | CHRM1 1205/4885BCL2 1871/4885BCL2L1 2559/4885 |
| US-20050113438-A1 | Substituted indoles | IDO2, IDO1, INMT | CHRM1 1205/4885BCL2 1871/4885BCL2L1 2559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.