Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.53 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | UQCRB | P14927 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5427166 | 0.88 | CHRM1 (0.56) | NR1I2SERPINE1CHRM1LMNAUQCRB | |
| SCHEMBL5430473 | 0.87 | NR1I2 (0.51) | NR1I2SERPINE1PTPN5GHSRLMNA | |
| SCHEMBL4359539 | 0.86 | L3MBTL1 (0.70) | L3MBTL1SERPINE1MAPK1CHRM1LMNA | |
| SCHEMBL3429738 | 0.79 | CHRM1 (0.65) | L3MBTL1MAPK1CHRM1LMNAALDH1A1 | |
| SCHEMBL28575852 | 0.77 | SLC22A12 (0.62) | L3MBTL1SERPINE1MAPK1CHRM1LMNA | |
| SCHEMBL5419821 | 0.76 | SERPINE1 (0.51) | NR1I2SERPINE1CHRM1ALDH1A1UQCRB | |
| SCHEMBL3564989 | 0.75 | PTPN5 (0.57) | SERPINE1PTPN5GHSRLMNAALDH1A1 | |
| SCHEMBL1606606 | 0.74 | LMNA (0.80) | L3MBTL1MAPK1CHRM1LMNAALDH1A1 | |
| SCHEMBL5422761 | 0.74 | EPHX2 (0.60) | NR1I2SERPINE1PTPN5GHSRLMNA | |
| SCHEMBL31693410 | 0.73 | TP53 (0.67) | L3MBTL1MAPK1CHRM1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | claimed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | claimed |
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | claimed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | claimed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | claimed |
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | disclosed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | IDO2, IDO1, INMT | NR1I2 2141/4885L3MBTL1 1992/4885SERPINE1 4834/4885 |
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | NR1I2 327/4885L3MBTL1 2991/4885SERPINE1 1/4885 |
| US-20050113438-A1 | Substituted indoles | IDO2, IDO1, INMT | NR1I2 2141/4885L3MBTL1 1992/4885SERPINE1 4834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.