Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.52 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542952 | 0.90 | IDO1 (0.49) | ENPP2ATXN2IDO1MGLLABHD6 | |
| SCHEMBL6236300 | 0.88 | ENPP2 (0.50) | ENPP2ATXN2IDO1MGLLABHD6 | |
| SCHEMBL4682405 | 0.88 | ENPP2 (0.52) | ENPP2ATXN2IDO1HPGDLMNA | |
| Hydrochloric Acid SCHEMBL4682398 | 0.86 | ENPP2 (0.51) | ENPP2ATXN2IDO1HPGDLMNA | |
| SCHEMBL543231 | 0.80 | MEN1 (0.55) | ENPP2ATXN2HPGDMEN1KMT2A | |
| SCHEMBL16094176 | 0.78 | ENPP2 (0.42) | ENPP2ATXN2IDO1CYP11B1CYP11B2 | |
| SCHEMBL542677 | 0.78 | MEN1 (0.53) | ENPP2ATXN2HPGDMEN1KMT2A | |
| SCHEMBL16825194 | 0.78 | GRIN2B (0.57) | ENPP2MEN1KMT2ATSHRLMNA | |
| SCHEMBL28032629 | 0.78 | KMT2A (0.64) | ENPP2ATXN2IDO1HPGDMEN1 | |
| SCHEMBL543132 | 0.77 | TACR1 (0.49) | ENPP2ATXN2IDO1MGLLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |