Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.50 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543019 | 0.88 | ENPP2 (0.52) | ENPP2ATXN2MEN1KMT2AMGLL | |
| SCHEMBL4682405 | 0.85 | ENPP2 (0.52) | ENPP2ATXN2IDO1RAB9A | |
| SCHEMBL6235265 | 0.85 | MEN1 (0.53) | MEN1KMT2ANPSR1IDO1FKBP1A | |
| Hydrochloric Acid SCHEMBL4682398 | 0.84 | ENPP2 (0.51) | ENPP2ATXN2IDO1RAB9A | |
| SCHEMBL542952 | 0.78 | IDO1 (0.49) | ENPP2ATXN2MEN1KMT2AMGLL | |
| SCHEMBL14425370 | 0.76 | ENPP2 (0.42) | ENPP2ATXN2MEN1KMT2A | |
| SCHEMBL5360981 | 0.76 | ENPP2 (0.42) | ENPP2ATXN2MEN1KMT2A | |
| SCHEMBL6235843 | 0.76 | MEN1 (0.55) | ENPP2ATXN2MEN1KMT2ANPSR1 | |
| SCHEMBL14255637 | 0.74 | IDO1 (0.58) | ENPP2ATXN2IDO1GAA | |
| SCHEMBL6235042 | 0.73 | MEN1 (0.62) | ENPP2ATXN2MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390034-A4 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1390034-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002080928-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2002-10-17 | — | — | WO | disclosed |