Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14584119 | 0.88 | CYP1A2 (0.40) | NPSR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14584225 | 0.81 | SMN1; SMN2 (0.45) | NPSR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14584125 | 0.80 | RORC (0.43) | CSNK2A2CSNK2BCSNK2A1PTGDR2FNTA | |
| SCHEMBL5444294 | 0.80 | NPSR1 (0.47) | NPSR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14584220 | 0.80 | ALDH1A1 (0.57) | NPSR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL31282458 | 0.78 | ALDH1A1 (0.45) | TSHRHIF1ASMN1; SMN2LMNAPTGDR2 | |
| SCHEMBL4498121 | 0.74 | MAPT (0.63) | CYP1A2CYP2C9CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL19779761 | 0.73 | KLKB1 (0.43) | CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL5433065 | 0.73 | LMNA (0.41) | NPSR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5433063 | 0.72 | TBXA2R (0.54) | NPSR1CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015263-A2 | LONIDAMINE ANALOGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | claimed |
| US-20070043057-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070043057-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070043057-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070015771-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | US | disclosed |
| WO-2006015263-A2 | LONIDAMINE ANALOGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015771-A1 | Lonidamine analogs | LONP1, LPXN, QDPR | NPSR1 2622/4885CYP1A2 4551/4885CYP3A4 4009/4885 |
| US-20070043057-A1 | Lonidamine analogs | LONP1, LPXN, QDPR | NPSR1 2622/4885CYP1A2 4551/4885CYP3A4 4009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.