Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294748 | 0.82 | TSHR (0.43) | TP53MAPTTDP1F2SIGMAR1 | |
| SCHEMBL2754177 | 0.79 | TP53 (0.41) | TP53MAPTTDP1F2SIGMAR1 | |
| SCHEMBL17078095 | 0.76 | TSHR (0.48) | TP53MAPTTDP1F2SIGMAR1 | |
| SCHEMBL6692681 | 0.76 | TSHR (0.44) | TP53MAPTTDP1F2SIGMAR1 | |
| SCHEMBL29469736 | 0.76 | SIGMAR1 (0.62) | MAPTSIGMAR1TSHRL3MBTL1KMT2A | |
| SCHEMBL4949707 | 0.76 | SIGMAR1 (0.62) | MAPTSIGMAR1TSHRL3MBTL1KMT2A | |
| SCHEMBL18762970 | 0.76 | F2 (0.43) | TP53MAPTTDP1F2SIGMAR1 | |
| SCHEMBL27947466 | 0.75 | ALDH1A1 (0.50) | TP53MAPTTSHRL3MBTL1ALDH1A1 | |
| SCHEMBL145553 | 0.73 | ALDH1A1 (0.59) | TP53MAPTTSHRL3MBTL1KMT2A | |
| SCHEMBL11381 | 0.72 | MLYCD (0.46) | TP53MAPTTDP1TSHRESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220768-B2 | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus | WYETH HOLDINGS CORP. (US) | 2007-05-22 | — | — | US | disclosed |