Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.49 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665307 | 0.86 | ALDH1A1 (0.81) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL8377299 | 0.85 | ALDH1A1 (0.58) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL4725328 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HPGDSMN1; SMN2HTTNPC1 | |
| SCHEMBL22804095 | 0.85 | TLR2 (0.50) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL8546246 | 0.85 | ALDH1A1 (0.56) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL16956513 | 0.83 | ALDH1A1 (0.42) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL16951625 | 0.83 | SMN1; SMN2 (0.42) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL28875403 | 0.83 | ALDH1A1 (0.59) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL30663744 | 0.83 | ALDH1A1 (0.59) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 | |
| SCHEMBL637169 | 0.82 | NPC1 (0.60) | ALDH1A1HPGDSMN1; SMN2HTTTLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070111989-A1 | Novel diazabicyclononene derivatives and use | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-05-17 | — | — | US | disclosed |
| CN-1890240-A | Diazabicyclononene derivatives and their use as renin inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2007-01-03 | — | — | CN | disclosed |
| EP-1692133-A1 | DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005054243-A1 | DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111989-A1 | Novel diazabicyclononene derivatives and use | REN, ACE, AGTR1 | ALDH1A1 305/4885HPGD 1080/4885SMN1; SMN2 4383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.