SCHEMBL8377299

SCHEMBL8377299

COCCOc1cccc(C=O)c1OC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
HPGD P15428 2/20 0.58
HTT P42858 1/20 0.58
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
SRC P12931 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
TLR2 O60603 1/20 0.47
ERN1 O75460 1/20 0.47
TLR1 Q15399 1/20 0.47
TLR6 Q9Y2C9 1/20 0.47
NFE2L2 Q16236 3/20 0.44
LMNA P02545 2/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
FDPS P14324 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30663744 0.92 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL28875403 0.92 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL1536736 0.88 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL637169 0.87 NPC1 (0.60) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL4683638 0.85 CA1 (0.53) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL5434859 0.85 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL1665307 0.84 ALDH1A1 (0.81) ALDH1A1SMN1; SMN2HPGDHTTSRC
SCHEMBL26731687 0.84 NPC1 (0.51) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL7787864 0.84 FDPS (0.45) ALDH1A1SMN1; SMN2HPGDHTTCA1
SCHEMBL16951406 0.84 NFE2L2 (0.41) ALDH1A1SMN1; SMN2HPGDHTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1744892-A Breast cancer resistance protein (BCRP) inhibitor YAKULT HONSHA KK (JP) 2006-03-08 CN disclosed
CN-1388120-A Intermediate used as new industrial products in preparation of new cephalosporin containing sbstituted benzyloxy imino on 7-position ROUSSEL UCLAF (FR) 2003-01-01 CN disclosed
US-5883248-A QUATERNARY AMMONIUM INTERMEDIATES ROUSSEL UCLAF (FR) 1999-03-16 US disclosed
US-5789434-A ACID, ESTER OR AMIDE DERIVATIVES AS ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS AND REDUCTION OF CARTILAGE DETERIORATION BAYER CORPORATION (US) 1998-08-04 US disclosed
US-5763617-A Cephalosporins ROUSSEL UCLAF (FR) 1998-06-09 US disclosed
US-5728828-A A 3-(3-CHLORO- OR IODOPROP-1-EN-1-YL),7-(2-AMINOTHIAZOL-4-YL) ((CARBOXY)(PHENYL)METHOXYIMINO)ACETAMIDO-3-CEPHEM; GRAMNEGATIVE AND -POSITIVE BACTERIA, ESP. ANTIBIOTIC-RESISTANCE STAPHYLOCOCCUS ROUSSEL UCLAF (FR) 1998-03-17 US disclosed
US-5712266-A Cephalosporins ROUSSEL UCLAF (FR) 1998-01-27 US disclosed
US-5710147-A ANTIBIOTICS ROUSSEL UCLAF (FR) 1998-01-20 US disclosed
CN-1152575-A Novel cephalosporins containing a substituted benzyloxyimino group in position 7, process and intermediates for their preparation and their use as medicaments ROUSSEL UCLAF (FR) 1997-06-25 CN disclosed
EP-0693496-A1 Novel cephalosporins having a substituted benzyloxyimino radical in position 7, process for their preparation and their use as medicaments ROUSSEL UCLAF (FR) 1996-01-24 EP disclosed