Sugi Predict

Sugi Predict / Compounds / SCHEMBL5435554

SCHEMBL5435554

SCHEMBL5435554

O=c1ccc(-c2ccc(F)cc2)cn1Cc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PTGDR2 Q9Y5Y4 4/20 0.54
▸ MKNK1 Q9BUB5 5/20 0.53
▸ MKNK2 Q9HBH9 5/20 0.53
▸ BRD4 O60885 3/20 0.52
▸ CREBBP Q92793 1/20 0.50
▸ BRD2 P25440 1/20 0.48
▸ BRD3 Q15059 1/20 0.48
▸ BRDT Q58F21 1/20 0.48
▸ HRH3 Q9Y5N1 1/20 0.46
▸ SDHB P21912 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.45
▸ SERPINE1 P05121 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ CYP11B1 P15538 1/20 0.44
▸ CYP11B2 P19099 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5445259 0.90 MKNK1 (0.58) PTGDR2MKNK1MKNK2BRD4CREBBP
SCHEMBL5445018 0.88 MKNK1 (0.54) PTGDR2MKNK1MKNK2BRD4CREBBP
SCHEMBL19939512 0.86 BRD4 (0.53) PTGDR2MKNK1MKNK2BRD4BRD2
SCHEMBL5437025 0.86 MAPT (0.59) PTGDR2MKNK1MKNK2CREBBPSDHB
SCHEMBL5444987 0.86 MKNK1 (0.60) PTGDR2MKNK1MKNK2BRD4SDHB
SCHEMBL5438403 0.85 MKNK1 (0.54) PTGDR2MKNK1MKNK2BRD4CREBBP
SCHEMBL16474464 0.84 DRD2 (0.44) PTGDR2CREBBPALDH1A1
SCHEMBL29242321 0.84 PTGDR2 (0.46) PTGDR2MKNK1MKNK2CREBBP
SCHEMBL5437566 0.84 BRD4 (0.59) PTGDR2MKNK1MKNK2BRD4CREBBP
SCHEMBL5439773 0.84 CREBBP (0.53) PTGDR2MKNK1MKNK2BRD4CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1799646-B1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS JANSSEN PHARMACEUTICALS INC (US) 2014-12-10 — — EP claimed
US-20130109652-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS ADDEX PHARMACEUTICALS S.A. (CH) 2013-05-02 — — US claimed
EP-2903991-B1 ANTI-FIBROTIC PYRIDINONES INTERMUNE INC (US) 2020-09-16 — — EP disclosed
US-10544161-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2020-01-28 — — US disclosed
US-20190321343-A1 Anti-Fibrotic Pyridinones GENENTECH, INC. 2019-10-24 — — US disclosed
US-10376497-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2019-08-13 — — US disclosed
US-20190144467-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2019-05-16 — — US disclosed
US-10233195-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2019-03-19 — — US disclosed
US-20180064692-A1 Anti-Fibrotic Pyridinones GENENTECH, INC. 2018-03-08 — — US disclosed
US-20180064692-A1 Anti-Fibrotic Pyridinones GENENTECH, INC. 2018-03-08 — — US disclosed
US-9675593-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2017-06-13 — — US disclosed
US-9359379-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2016-06-07 — — US disclosed
US-9359379-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2016-06-07 — — US disclosed
WO-2015153683-A1 ANTI-FIBROTIC PYRIDINONES INTERMUNE, INC. (US) 2015-10-08 — — WO disclosed
EP-1799646-B1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS JANSSEN PHARMACEUTICALS INC (US) 2014-12-10 — — EP disclosed
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2014-04-17 — — US disclosed
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2014-04-17 — — US disclosed
US-20130109652-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS ADDEX PHARMACEUTICALS S.A. (CH) 2013-05-02 — — US disclosed
US-8399493-B2 Pyridinone derivatives and their use as positive allosteric modulators of mGluR2-receptors Janssen Pharmaceuticals, Inc. (US) 2013-03-19 — — US disclosed
US-20070213323-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS Janssen Pharmaceuticals, Inc. 2007-09-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180064692-A1 Anti-Fibrotic Pyridinones MMP1, COL1A1, COL2A1 PTGDR2 787/4885MKNK1 3297/4885MKNK2 2924/4885
US-10544161-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 PTGDR2 787/4885MKNK1 3297/4885MKNK2 2924/4885
US-20190321343-A1 Anti-Fibrotic Pyridinones MMP1, COL1A1, COL2A1 PTGDR2 787/4885MKNK1 3297/4885MKNK2 2924/4885
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 PTGDR2 787/4885MKNK1 3297/4885MKNK2 2924/4885
US-20070213323-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS GRM2, GRM1, GRM3 PTGDR2 85/4885MKNK1 2293/4885MKNK2 1366/4885
US-10233195-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 PTGDR2 787/4885MKNK1 3297/4885MKNK2 2924/4885
US-10376497-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 PTGDR2 787/4885MKNK1 3297/4885MKNK2 2924/4885
US-20130109652-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS GRM2, GRM1, GRIA2 PTGDR2 78/4885MKNK1 1868/4885MKNK2 1100/4885
US-20190144467-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 PTGDR2 787/4885MKNK1 3297/4885MKNK2 2924/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.