Tofa

Tofa

SCHEMBL543676

CCCCCCCCCCCCCCOc1ccc(C(=O)O)o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
TP53 P04637 1/20 0.51
TSHR P16473 1/20 0.51
PLA2G4B P0C869 6/20 0.50
RARB P10826 3/20 0.48
PLA2G2A P14555 1/20 0.47
PLA2G4A P47712 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11561346 1.00 MEN1 (1.00) MEN1KMT2ATDP1TP53TSHR
SCHEMBL992112 1.00 MEN1 (1.00) MEN1KMT2ATDP1TP53TSHR
SCHEMBL9060429 1.00 MEN1 (1.00) MEN1KMT2ATDP1TP53TSHR
SCHEMBL11558887 1.00 MEN1 (1.00) MEN1KMT2ATDP1TP53TSHR
SCHEMBL13193431 1.00 MEN1 (1.00) MEN1KMT2ATDP1TP53TSHR
Tofa SCHEMBL11555343 0.98 MEN1 (0.97) MEN1KMT2ATDP1TP53TSHR
SCHEMBL8784383 0.98 KMT2A (0.97) MEN1KMT2ATDP1TP53TSHR
SCHEMBL10669914 0.92 TDP1 (0.84) MEN1KMT2ATDP1TP53TSHR
SCHEMBL10669926 0.92 TDP1 (0.84) MEN1KMT2ATDP1TP53TSHR
SCHEMBL10423243 0.92 TDP1 (0.84) MEN1KMT2ATDP1TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 952 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260034091-A1 Compositions and Methods for Treating Metabolic Disorders UNIV CALIFORNIA (US) 2026-02-05 US claimed
US-20250297321-A1 METHOD FOR DETECTING METABOLIC REPROGRAMING OF CANCER TOWARDS FATTY ACIDS METABOLISM INST NAT SANTE RECH MED (FR) 2025-09-25 US claimed
EP-4561557-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS The Regents of the University of California (US) 2025-06-04 EP claimed
US-20250161886-A1 ZINC IMIDAZOLE SALICYLALDOXIME-BASED ADSORPTIVE MEMBRANES FOR REMOVAL OF METAL IONS FROM AQUEOUS SOLUTIONS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2025-05-22 US claimed
CN-119969979-A Monitoring method and system for care of home elderly cerebral apoplexy patients 徐州医科大学 2025-05-13 CN claimed
CN-119855586-A Compositions and methods for treating metabolic disorders 加利福尼亚大学董事会 2025-04-18 CN claimed
CN-119548487-A Application of 5- (tetradecyloxy) -2-furoic acid in preparation of medicines for inhibiting osteoclast differentiation and function 浙江工业大学 2025-03-04 CN claimed
WO-2025029574-A2 ZINC IMIDAZOLE SALICYLALDOXIME-BASED ADSORPTIVE MEMBRANES FOR REMOVAL OF METAL IONS FROM AQUEOUS SOLUTIONS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2025-02-06 WO claimed
EP-2836534-B1 HIGH FUNCTIONAL POLYESTER POLYOLS HUNTSMAN INT LLC (US) 2024-12-25 EP claimed
EP-4469602-A1 METHOD FOR DETECTING METABOLIC REPROGRAMING OF CANCER TOWARDS FATTY ACIDS METABOLISM Université Paris Cité (FR) 2024-12-04 EP claimed
EP-0738107-A1 INHIBITORS OF FATTY ACID SYNTHESIS AS ANTIMICROBIAL AGENTS THE JOHNS HOPKINS UNIVERSITY (US) 1996-10-23 EP claimed
WO-1996013519-A1 ACTIVATION OF A HUMAN STEROID RECEPTOR MERCK & CO., INC. (US) 1996-05-09 WO claimed
WO-1996013257-A1 USE OF RECEPTOR POTENTIATORS MERCK & CO., INC. (US) 1996-05-09 WO claimed
WO-1995019706-A1 INHIBITORS OF FATTY ACID SYNTHESIS AS ANTIMICROBIAL AGENTS THE JOHNS HOPKINS UNIVERSITY (US) 1995-07-27 WO claimed
WO-1995019765-A1 CERTAIN CERULENIN-GERANYL AND DODECANOIC ACID DERIVATIVES CHEKTEC CORPORATION (US) 1995-07-27 WO claimed
EP-0651636-A1 CHEMOTHERAPY FOR CANCER THE JOHNS HOPKINS UNIVERSITY (US) 1995-05-10 EP claimed
WO-1994021230-A1 METHOD AND COMPOSITIONS FOR DISRUPTING THE EPITHELIAL BARRIER FUNCTION CELLEGY PHARMACEUTICALS, INC. (US) 1994-09-29 WO claimed
WO-1994002108-A1 CHEMOTHERAPY FOR CANCER THE JOHNS HOPKINS UNIVERSITY (US) 1994-02-03 WO claimed
US-4146623-A SUBSTITUTED FUROIC ACIDS AND ESTERS RICHARDSON-MERRELL INC. (US) 1979-03-27 US claimed
US-4110351-A Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts RICHARDSON-MERRELL INC. (US) 1978-08-29 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260034091-A1 Compositions and Methods for Treating Metabolic Disorders LIPC, GPR119, PNLIP MEN1 3713/4885KMT2A 3144/4885TDP1 4755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.