Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 4/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543687 | 0.85 | KDM4E (0.55) | SLC7A5LNPEPHPGDSMN1; SMN2KDM4E | |
| SCHEMBL13841055 | 0.84 | CCNC (0.51) | SLC7A5PLK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3956859 | 0.84 | MAPK1 (0.41) | LNPEPSLC6A2SLC6A4SLC6A3HPGD | |
| SCHEMBL10079433 | 0.81 | ALDH1A1 (0.37) | LNPEPHDAC8HPGDSMN1; SMN2HTT | |
| SCHEMBL544786 | 0.79 | PDK1 (0.47) | SMN1; SMN2TSHRHTTALDH1A1MAPT | |
| SCHEMBL31495814 | 0.79 | PLAU (0.46) | SLC7A5PLK1HDAC8PLAUHPGD | |
| SCHEMBL4235473 | 0.74 | KDM4E (0.51) | SLC7A5LNPEPHPGDSMN1; SMN2TSHR | |
| SCHEMBL29582662 | 0.72 | PLAU (0.53) | SLC7A5PLK1LNPEPHDAC8PLAU | |
| SCHEMBL940919 | 0.72 | PLAU (0.53) | SLC7A5PLK1LNPEPHDAC8PLAU | |
| SCHEMBL2303854 | 0.72 | ALDH1A1 (0.69) | PLK1SLC6A2SLC6A4SLC6A3PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110688-B2 | Method for producing indole derivative having piperidine ring | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-02-07 | — | — | US | disclosed |
| US-8110688-B2 | Method for producing indole derivative having piperidine ring | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-02-07 | — | — | US | disclosed |
| EP-1880995-B1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | EISAI R&D MAN CO LTD (JP) | 2011-12-21 | — | — | EP | disclosed |
| US-20100197926-A1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-20100197926-A1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| EP-1880995-A1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | Eisai R&D Management Co., Ltd. (JP) | 2008-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197926-A1 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING | IDO2, IDO1, TPH2 | SLC7A5 3976/4885PLK1 4336/4885LNPEP 4084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.