SCHEMBL5437594

SCHEMBL5437594

NC1=CC(c2ccccc2)CC=C1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 10/20 0.34
MAOA P21397 9/20 0.34
KDM1A O60341 7/20 0.34
CYP2C19 P33261 4/20 0.34
CYP2B6 P20813 3/20 0.34
TAAR1 Q96RJ0 3/20 0.34
CYP1A2 P05177 2/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2C9 P11712 2/20 0.34
LMNA P02545 2/20 0.34
CYP3A4 P08684 1/20 0.34
HTR1A P08908 1/20 0.34
ADRA2A P08913 1/20 0.34
CYP2A6 P11509 1/20 0.34
SLC6A2 P23975 1/20 0.34
HTR2C P28335 1/20 0.34
ADRA1A P35348 1/20 0.34
DRD3 P35462 1/20 0.34
SLC6A3 Q01959 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22475296 0.76 SLC18A3 (0.32) MAOBMAOAKDM1ACYP2C19CYP2B6
SCHEMBL12673469 0.76 SLC18A3 (0.36) KDM1ASLC18A3SIGMAR1GAAMAPT
SCHEMBL29678250 0.74 SLC18A3 (0.31) MAOBMAOAKDM1ASLC18A3SIGMAR1
SCHEMBL5718734 0.73 CA2 (0.35) MAOAKDM1ALMNAGAAMAPT
SCHEMBL886018 0.73 PARP1 (0.35) MAOAKDM1ACYP2C19CYP3A4HSD17B10
SCHEMBL22665208 0.72 MAOA (0.44) MAOALMNACYP3A4HSD17B10MAPT
SCHEMBL5317110 0.72 CA1 (0.38) HSD17B10SLC18A3SIGMAR1GAAMAPT
SCHEMBL24612947 0.71 MAPT (0.39) HSD17B10GAAMAPT
SCHEMBL10252203 0.70 ALDH1A1 (0.36) HSD17B10
Water SCHEMBL15069642 0.68 KDM4E (0.38) GAAMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007515485-A 2007-06-14 JP claimed
EP-1699785-A2 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES ABBOTT LABORATORIES (US) 2006-09-13 EP claimed
WO-2005066166-A2 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES ABBOTT LABORATORIES (US) 2005-07-21 WO claimed
EP-3193384-B1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO LTD (KR) 2021-04-28 EP disclosed
CN-102325755-B Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds ARQULE INC 2015-07-01 CN disclosed
CN-102325755-A Substituted 5,6-dihydro-6-phenyl benzo [F] isoquinoline 99.9-2-amine compound ARQULE INC 2012-01-18 CN disclosed
EP-1699785-A2 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES ABBOTT LABORATORIES (US) 2006-09-13 EP disclosed
WO-2005066166-A2 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES ABBOTT LABORATORIES (US) 2005-07-21 WO disclosed