Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5442036 | 1.00 | DYRK1A (0.53) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL31214345 | 0.81 | DYRK1A (0.72) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL23480164 | 0.73 | DYRK1A (0.57) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL6032917 | 0.73 | DYRK1A (0.62) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL27558183 | 0.71 | DYRK1A (0.60) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL16573976 | 0.71 | DYRK1A (0.60) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL22130152 | 0.71 | DYRK1A (0.70) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL24155396 | 0.71 | DYRK1A (0.60) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL6658073 | 0.71 | DYRK1A (0.60) | DYRK1AL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL17691820 | 0.70 | DYRK1A (0.63) | DYRK1AL3MBTL1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249639-A1 | Use of 9H-Purine-2,6-Diamine Derivatives in the Treatment of Proliferative Diseases and Novel 9H-Purine-2,6-Diamine Derivatives | BAENTELI ROLF | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249639-A1 | Use of 9H-Purine-2,6-Diamine Derivatives in the Treatment of Proliferative Diseases and Novel 9H-Purine-2,6-Diamine Derivatives | HPRT1, NUDT1, DPYD | DYRK1A 1159/4885L3MBTL1 3821/4885NPC1 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.