Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.70 |
| ▸ | CCND1 | P24385 | 8/20 | 0.70 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.70 |
| ▸ | CDK2 | P24941 | 5/20 | 0.70 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.70 |
| ▸ | CDK1 | P06493 | 4/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.70 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.70 |
| ▸ | CAMK2B | Q13554 | 6/20 | 0.59 |
| ▸ | CAMK2G | Q13555 | 6/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 6/20 | 0.59 |
| ▸ | CAMK2A | Q9UQM7 | 6/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | PRKCA | P17252 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438544 | 0.87 | PRKCA (0.71) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14708732 | 0.79 | ROCK2 (0.58) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL22470379 | 0.77 | CCNE2 (0.68) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL29391829 | 0.77 | CCNE2 (0.68) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6081666 | 0.77 | CDK4 (0.46) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL31237530 | 0.77 | CDK4 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8122606 | 0.76 | CDK4 (0.77) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL16504230 | 0.75 | CDK4 (0.60) | CDK4CCND1PRKCAROCK2GABRP | |
| SCHEMBL14440328 | 0.75 | PRKCA (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14440332 | 0.75 | PRKCA (0.53) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249590-A1 | Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249590-A1 | Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249590-A1 | Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249590-A1 | Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders | PRKACA, PRKDC, PACSIN2 | CDK4 129/4885CCND1 1443/4885CCNE2 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.