Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 6/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435124 | 0.87 | CXCR2 (0.49) | CXCR2POLBLMNAMETAP2RNASEH1 | |
| SCHEMBL5442314 | 0.80 | CXCR2 (0.61) | CXCR2POLBLMNAMETAP2RNASEH1 | |
| SCHEMBL3856241 | 0.74 | CXCR2 (0.61) | CXCR2TP53CX3CR1 | |
| SCHEMBL5442268 | 0.69 | CXCR2 (0.51) | CXCR2CX3CR1 | |
| SCHEMBL1806643 | 0.65 | L3MBTL1 (0.56) | POLBLMNAMETAP2PKML3MBTL1 | |
| SCHEMBL10464789 | 0.65 | L3MBTL1 (0.55) | LMNAMETAP2RNASEH1PKML3MBTL1 | |
| SCHEMBL10464790 | 0.64 | L3MBTL1 (0.51) | METAP2RNASEH1PKML3MBTL1MEN1 | |
| SCHEMBL20872587 | 0.64 | L3MBTL1 (0.48) | POLBMETAP2RNASEH1PKML3MBTL1 | |
| SCHEMBL29628550 | 0.64 | L3MBTL1 (0.48) | POLBMETAP2RNASEH1PKML3MBTL1 | |
| SCHEMBL20477252 | 0.63 | RNASEH1 (0.68) | POLBLMNARNASEH1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142386-A1 | New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1 | ASTRAZENECA (SE) | 2007-06-21 | — | — | US | disclosed |
| EP-1675862-A1 | NEW 2-SUBSTITUTED, 4-AMINO-THIAZOLO 4,5-D PYRIMIDINES, USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS, ESP. CX3CR1 | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005033115-A1 | NEW 2-SUBSTITUTED, 4-AMINO-THIAZOLO[4,5-D] PYRIMIDINES, USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS, ESP. CX3CR1 | ASTRAZENECA AB (SE) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142386-A1 | New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1 | CX3CR1, CCR2, CXCR4 | CXCR2 6/4885POLB 2926/4885LMNA 4307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.