Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453005 | 0.89 | PPARA (0.45) | TSHRHTR1ASLC6A4KMT2ANOTUM | |
| SCHEMBL5450510 | 0.81 | P2RX4 (0.40) | KMT2A | |
| SCHEMBL5452847 | 0.81 | ALDH1A1 (0.44) | KMT2ANOTUMMAPTALDH1A1POLB | |
| SCHEMBL5456844 | 0.81 | CHRM1 (0.52) | KMT2AKCNH2ALDH1A1POLB | |
| SCHEMBL4252335 | 0.81 | TSHR (0.43) | TSHRKMT2AMAPTHPGDRXFP1 | |
| SCHEMBL5444659 | 0.78 | KMT2A (0.40) | TSHRHTR1ASLC6A4KMT2ANOTUM | |
| SCHEMBL5450713 | 0.76 | KDM1A (0.48) | TSHRHTR1ASLC6A4KMT2AKCNH2 | |
| SCHEMBL5442407 | 0.75 | PPARG (0.47) | — | |
| SCHEMBL5456798 | 0.75 | HDAC6 (0.44) | — | |
| SCHEMBL5460714 | 0.73 | NPSR1 (0.45) | TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105847-A1 | 1,3-Dioxane derivatives and analogues thereof useful in the treatment of i.a. obesity and diabetes | CADILA HEALTHCARE LIMITED (IN) | 2007-05-10 | — | — | US | claimed |
| EP-1709035-A1 | 1 , 3 - DIOXANE DERIVATIVES AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF I.A. OBESITY AND DIABETES | CADILA HEALTHCARE LTD. (IN) | 2006-10-11 | — | — | EP | claimed |
| WO-2005077943-A1 | 1 , 3 - DIOXANE DERIVATIVES AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF I.A. OBESITY AND DIABETES | CADILA HEALTHCARE LIMITED (IN) | 2005-08-25 | — | — | WO | claimed |
| US-20070105847-A1 | 1,3-Dioxane derivatives and analogues thereof useful in the treatment of i.a. obesity and diabetes | CADILA HEALTHCARE LIMITED (IN) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105847-A1 | 1,3-Dioxane derivatives and analogues thereof useful in the treatment of i.a. obesity and diabetes | GPR119, PPARG, FABP4 | TSHR 623/4885HTR1A 970/4885SLC6A4 3993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.