Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGAV | P06756 | 2/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5302265 | 0.93 | EPHX2 (0.48) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6015067 | 0.85 | KDM4E (0.51) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2299633 | 0.83 | HTR1E (0.53) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5294218 | 0.83 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5279074 | 0.83 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2LMNAITGB3 | |
| SCHEMBL2291392 | 0.82 | KMT2A (0.51) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2294942 | 0.82 | HDAC3 (0.44) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2296670 | 0.81 | NR1I2 (0.47) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2296252 | 0.81 | NR1I2 (0.47) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2299814 | 0.80 | LMNA (0.45) | NPC1RAB9ASMN1; SMN2LMNAFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |