Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13172811 | 0.83 | L3MBTL1 (0.44) | ALDH1A1LMNAL3MBTL1HTTNPSR1 | |
| SCHEMBL4228563 | 0.83 | CACNA2D1 (0.53) | ALDH1A1L3MBTL1HTTCACNA2D1CACNA1B | |
| Hydrochloric Acid SCHEMBL12985522 | 0.82 | L3MBTL1 (0.43) | ALDH1A1LMNAL3MBTL1HTTNPSR1 | |
| SCHEMBL5453472 | 0.79 | L3MBTL1 (0.43) | ALDH1A1LMNAL3MBTL1HTTNPSR1 | |
| SCHEMBL5467799 | 0.77 | CACNA2D1 (0.47) | ALDH1A1LMNAL3MBTL1HTTCACNA2D1 | |
| SCHEMBL30662759 | 0.73 | MEN1 (0.53) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL12984920 | 0.73 | MEN1 (0.53) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL12984530 | 0.73 | KCNQ2 (0.41) | ALDH1A1L3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL5451862 | 0.73 | DRD2 (0.49) | ALDH1A1LMNACACNA2D1CACNA1BCACNB1 | |
| SCHEMBL5460735 | 0.73 | CACNA2D1 (0.44) | ALDH1A1LMNAL3MBTL1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043024-A1 | Azacyclic compounds as inhibitors of sensory neurone specific channels | IONIX PHARMACEUTICALS LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| EP-1660454-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS | Vernalis (R&D) Limited (GB) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005005392-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043024-A1 | Azacyclic compounds as inhibitors of sensory neurone specific channels | SCN1B, SCN1A, SCN10A | ALDH1A1 489/4885LMNA 1282/4885L3MBTL1 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.