Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5460735 | 0.95 | CACNA2D1 (0.44) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL5449575 | 0.86 | DRD2 (0.42) | ALDH1A1DRD2DRD3MAPTL3MBTL1 | |
| SCHEMBL5453618 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL5456255 | 0.84 | RAB9A (0.47) | ALDH1A1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL4228563 | 0.84 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL5451862 | 0.83 | DRD2 (0.49) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL5453386 | 0.83 | MEN1 (0.44) | DRD2DRD1DRD5DRD3MEN1 | |
| SCHEMBL5750755 | 0.83 | DRD1 (0.44) | ALDH1A1DRD2DRD1DRD5DRD3 | |
| SCHEMBL5453790 | 0.81 | DRD2 (0.46) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL5451932 | 0.79 | DRD1 (0.43) | DRD2DRD1DRD5DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043024-A1 | Azacyclic compounds as inhibitors of sensory neurone specific channels | IONIX PHARMACEUTICALS LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| EP-1660454-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS | Vernalis (R&D) Limited (GB) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005005392-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043024-A1 | Azacyclic compounds as inhibitors of sensory neurone specific channels | SCN1B, SCN1A, SCN10A | CACNA2D1 105/4885CACNA1B 4/4885CACNB1 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.