Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447476 | 0.71 | POLB (0.43) | POLBPTGS2RORCALDH1A1MAPT | |
| SCHEMBL5441968 | 0.71 | MAPT (0.39) | POLBPTGS2FEN1RORCALDH1A1 | |
| SCHEMBL5441973 | 0.69 | HTR6 (0.40) | POLBPTGS2FEN1ALDH1A1MAPT | |
| SCHEMBL5437204 | 0.67 | FEN1 (0.39) | POLBFEN1RORCALDH1A1KDM4E | |
| SCHEMBL5440852 | 0.65 | POLB (0.42) | POLBALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5441969 | 0.62 | EGFR (0.43) | PTGS2FEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL5448780 | 0.62 | CA5A (0.48) | POLBRORCALDH1A1MAPTHTT | |
| (Phenylsulfonyl)Benzene SCHEMBL17092887 | 0.61 | ALDH1A1 (0.61) | PTGS2FEN1ALDH1A1KDM4EHTT | |
| Carbazole SCHEMBL28455411 | 0.59 | ALDH1A1 (0.64) | ALDH1A1KDM4EMAPTHTTKMT2A | |
| SCHEMBL10749372 | 0.59 | CYP19A1 (0.58) | POLBALDH1A1KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004684-A1 | Alpha-Carbolines as CDK-1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004684-A1 | Alpha-Carbolines as CDK-1 inhibitors | CDKL1, CDK1, CCNA1 | POLB 323/4885PTGS2 2534/4885FEN1 1081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.