Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440875 | 0.83 | CNR1 (0.55) | CNR1CYP3A4CYP2C19PTGS2GABRA2 | |
| SCHEMBL5445432 | 0.81 | GABRA2 (0.66) | CNR1CYP3A4CYP2C19PTGS2GABRA2 | |
| SCHEMBL14339087 | 0.81 | CNR1 (0.57) | CNR1CYP3A4CYP2C19PTGS2GABRA2 | |
| SCHEMBL5450853 | 0.78 | CNR1 (0.51) | CNR1CYP3A4CYP2C19PTGS2GABRA2 | |
| SCHEMBL5440906 | 0.77 | CNR1 (0.50) | CNR1CYP3A4CYP2C19PTGS2GABRA2 | |
| SCHEMBL5449238 | 0.75 | PTGS2 (0.48) | CNR1CYP3A4CYP2C19PTGS2ALDH1A1 | |
| SCHEMBL5370038 | 0.74 | CNR1 (0.62) | CNR1GABRA2GABRB2CNR2 | |
| SCHEMBL5816285 | 0.71 | CNR1 (0.48) | CNR1PTGS2GABRA2GABRB2ALDH1A1 | |
| SCHEMBL5818847 | 0.70 | GABRA2 (0.58) | CNR1GABRA2GABRB2ALDH1A1HPGD | |
| SCHEMBL5443076 | 0.70 | CCNE1 (0.45) | CNR1CYP3A4CYP2C19PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070191448-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-16 | — | — | US | disclosed |
| EP-1722786-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005086902-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | CACNA1B, CACNA1C, TRPV1 | CNR1 293/4885CYP3A4 4085/4885CYP2C19 4481/4885 |
| US-20070191448-A1 | Ion channel modulators | CACNA1B, CACNA1C, TRPV1 | CNR1 293/4885CYP3A4 4085/4885CYP2C19 4481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.