Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948208 | 0.88 | PTGS2 (0.55) | PTGS2CNR1CA1CA2CA9 | |
| SCHEMBL5443076 | 0.79 | CCNE1 (0.45) | PTGS2CYP3A4CYP2C19CNR1ALDH1A1 | |
| SCHEMBL5440875 | 0.79 | CNR1 (0.55) | PTGS2CYP3A4CYP2C19CNR1UGCG | |
| SCHEMBL5445432 | 0.77 | GABRA2 (0.66) | PTGS2CYP3A4CYP2C19CNR1GAA | |
| SCHEMBL5444900 | 0.76 | CNR1 (0.56) | PTGS2CNR1ALDH1A1MAPTKDM4E | |
| SCHEMBL5447115 | 0.75 | RAB9A (0.51) | PTGS2CNR1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5450849 | 0.75 | CNR1 (0.56) | PTGS2CYP3A4CYP2C19CNR1ALDH1A1 | |
| SCHEMBL5450853 | 0.74 | CNR1 (0.51) | PTGS2CYP3A4CYP2C19CNR1UGCG | |
| SCHEMBL5174504 | 0.74 | CNR1 (0.53) | PTGS2CNR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5440906 | 0.73 | CNR1 (0.50) | PTGS2CYP3A4CYP2C19CNR1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070197513-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197513-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197513-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| EP-1723119-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| EP-1723117-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087747-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005086836-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | CACNA1B, CACNA1C, TRPV1 | PTGS2 1158/4885CYP3A4 4085/4885CYP2C19 4481/4885 |
| US-20070197513-A1 | Ion channel modulators | CACNA1B, CACNA1C, TRPV1 | PTGS2 1158/4885CYP3A4 4085/4885CYP2C19 4481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.