Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.50 |
| ▸ | CCKAR | P32238 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440875 | 0.84 | CNR1 (0.55) | CNR1CCKARGABRA2GABRB2PTGS2 | |
| SCHEMBL5445432 | 0.80 | GABRA2 (0.66) | CNR1GABRA2GABRB2PTGS2CYP3A4 | |
| SCHEMBL5450853 | 0.79 | CNR1 (0.51) | CNR1CCKARGABRA2GABRB2PTGS2 | |
| SCHEMBL5447115 | 0.78 | RAB9A (0.51) | CNR1CCKARPTGS2AVPR2OXTR | |
| SCHEMBL5450849 | 0.77 | CNR1 (0.56) | CNR1GABRA2GABRB2PTGS2CYP3A4 | |
| SCHEMBL14339087 | 0.76 | CNR1 (0.57) | CNR1GABRA2GABRB2PTGS2CYP3A4 | |
| SCHEMBL5449238 | 0.73 | PTGS2 (0.48) | CNR1PTGS2CYP3A4CYP2C19CA1 | |
| SCHEMBL5816285 | 0.72 | CNR1 (0.48) | CNR1CCKARGABRA2GABRB2PTGS2 | |
| SCHEMBL6688666 | 0.72 | GABRA2 (0.59) | CNR1GABRA2GABRB2 | |
| SCHEMBL15151734 | 0.71 | GABRA2 (0.46) | CCKARGABRA2GABRB2ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070191448-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191448-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191448-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-16 | — | — | US | disclosed |
| EP-1722786-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| EP-1723117-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005086902-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005086836-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | CACNA1B, CACNA1C, TRPV1 | CNR1 293/4885CCKAR 1076/4885GABRA2 267/4885 |
| US-20070191448-A1 | Ion channel modulators | CACNA1B, CACNA1C, TRPV1 | CNR1 293/4885CCKAR 1076/4885GABRA2 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.