Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447426 | 0.89 | PGR (0.39) | PGRBACE1PPARGMAPT | |
| SCHEMBL5457662 | 0.84 | PSEN1 (0.40) | PGRBACE1ALOX5PSEN1PSEN2 | |
| SCHEMBL5448815 | 0.82 | ADORA2A (0.39) | BACE1ALOX5PSEN1PSEN2APH1B | |
| SCHEMBL5442944 | 0.81 | GRIK1 (0.52) | BACE1APPNPSR1KDM4EALDH1A1 | |
| SCHEMBL5447364 | 0.81 | PTPN7 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5453566 | 0.77 | ALOX5 (0.39) | PGRALOX5NPSR1CYP19A1KDM4E | |
| SCHEMBL5535418 | 0.75 | PGR (0.46) | PGRBACE1APPARNPSR1 | |
| SCHEMBL5448832 | 0.75 | ESR2 (0.56) | PGRCYP19A1KDM4EALDH1A1HPGD | |
| SCHEMBL5444129 | 0.73 | PPARG (0.63) | PPARG | |
| SCHEMBL5447485 | 0.73 | MAOB (0.38) | PGRALOX5PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123495-A1 | PYRROLO-NAPHTHYL ACIDS AND METHODS FOR USING THEM | WYETH (US) | 2007-05-31 | — | — | US | disclosed |
| EP-1781641-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | Wyeth (US) | 2007-05-09 | — | — | EP | disclosed |
| US-7186749-B2 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2007-03-06 | — | — | US | disclosed |
| US-20060052349-A1 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2006-03-09 | — | — | US | disclosed |
| WO-2006023864-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123495-A1 | PYRROLO-NAPHTHYL ACIDS AND METHODS FOR USING THEM | SERPINE1, SERPINC1, SERPINB1 | PGR 669/4885BACE1 1848/4885ALOX5 157/4885 |
| US-20060052349-A1 | Pyrrolo-naphthyl acids and methods for using them | SERPINE1, SERPINC1, SERPINB1 | PGR 669/4885BACE1 1848/4885ALOX5 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.