Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.59 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | ACP1 | P24666 | 4/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5455135 | 1.00 | MAPK1 (0.59) | MAPK1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5469841 | 0.87 | MAPK1 (0.62) | MAPK1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5469842 | 0.87 | MAPK1 (0.62) | MAPK1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5464405 | 0.86 | ENPP2 (0.70) | ENPP2PTPN1ACP1PTPN2PTPRF | |
| SCHEMBL5464400 | 0.86 | ENPP2 (0.70) | ENPP2PTPN1ACP1PTPN2PTPRF | |
| SCHEMBL5460593 | 0.84 | PTPN1 (0.54) | MEN1KMT2APOLBENPP2PTPN1 | |
| SCHEMBL5460594 | 0.84 | PTPN1 (0.54) | MEN1KMT2APOLBENPP2PTPN1 | |
| SCHEMBL5465627 | 0.83 | PTPN1 (0.56) | MAPK1MEN1MAPTKMT2APOLB | |
| SCHEMBL5465629 | 0.83 | PTPN1 (0.56) | MAPK1MEN1MAPTKMT2APOLB | |
| SCHEMBL5461413 | 0.82 | NLRP3 (0.56) | MEN1KMT2APOLBENPP2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1666469-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | MAPK1 256/4885MEN1 2892/4885ALDH1A1 1861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.