Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334693 | 0.86 | TP53 (0.68) | LMNAALDH1A1HPGDHTTFGFR1 | |
| SCHEMBL4908388 | 0.86 | PIP4K2C (0.61) | LMNAALDH1A1HPGDHTTFGFR1 | |
| Hydrochloric Acid SCHEMBL810092 | 0.85 | PIP4K2C (0.60) | LMNAALDH1A1HPGDHTTFGFR1 | |
| SCHEMBL3345046 | 0.83 | TP53 (0.69) | LMNAALDH1A1HPGDHTTFGFR1 | |
| SCHEMBL5463611 | 0.82 | MAPT (0.62) | LMNAALDH1A1HPGDHTTFGFR1 | |
| Hydrochloric Acid SCHEMBL5474323 | 0.81 | MAPT (0.61) | LMNAALDH1A1HPGDHTTFGFR1 | |
| SCHEMBL5467454 | 0.81 | MAPT (0.54) | LMNAALDH1A1HPGDHTTFGFR1 | |
| SCHEMBL3342319 | 0.81 | CCNC (0.70) | LMNAALDH1A1HPGDHTTFGFR1 | |
| Hydrochloric Acid SCHEMBL5462520 | 0.80 | MAPT (0.53) | LMNAALDH1A1HPGDHTTFGFR1 | |
| SCHEMBL12392601 | 0.80 | LMNA (0.48) | LMNAALDH1A1HPGDHTTFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213305-A1 | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-20070213305-A1 | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-20070213305-A1 | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| WO-2007056214-A2 | N-ALKYL-N-ARYL-THIENOPYRIMIDIN-R-AMINES AND USES THEREOF | CYTOVIA, INC (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213305-A1 | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP10, CASP4, CASP3 | LMNA 369/4885ALDH1A1 1247/4885HPGD 2073/4885 |
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP4, CASP3, API5 | LMNA 822/4885ALDH1A1 1132/4885HPGD 1628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.