Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5457281 | 0.93 | GSK3A (0.50) | ALDH1A1GSK3AGSK3BPPARGHDAC1 | |
| SCHEMBL5457426 | 0.84 | GSK3A (0.68) | ALDH1A1GSK3AGSK3BPPARGKDM4E | |
| SCHEMBL7463278 | 0.75 | GSK3A (0.61) | ALDH1A1GSK3AGSK3BPPARGHDAC1 | |
| SCHEMBL5457394 | 0.75 | ALDH1A1 (0.53) | ALDH1A1GSK3AGSK3BGAASMN1; SMN2 | |
| SCHEMBL5462796 | 0.75 | GSK3A (0.74) | ALDH1A1GSK3AGSK3BPPARGHDAC1 | |
| SCHEMBL27854365 | 0.75 | MEN1 (0.53) | ALDH1A1KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL5460257 | 0.74 | MEN1 (0.52) | PPARGLMNAMAPT | |
| SCHEMBL5457280 | 0.73 | GSK3A (0.53) | ALDH1A1GSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL26710431 | 0.72 | GSK3A (0.65) | ALDH1A1GSK3AGSK3BPPARGKDM4E | |
| SCHEMBL338442 | 0.71 | GSK3A (1.00) | ALDH1A1GSK3AGSK3BPPARGHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1666469-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | ALDH1A1 1861/4885GSK3A 2857/4885GSK3B 2838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.