Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.53 |
| ▸ | USP2 | O75604 | 11/20 | 0.53 |
| ▸ | CASP1 | P29466 | 11/20 | 0.53 |
| ▸ | CASP7 | P55210 | 11/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.53 |
| ▸ | MEN1 | O00255 | 10/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 9/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.48 |
| ▸ | TSHR | P16473 | 7/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.48 |
| ▸ | HBB | P68871 | 3/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451875 | 0.82 | ADORA1 (0.57) | ADORA1ADORA2AALDH1A1CYP1A2USP2 | |
| SCHEMBL7215273 | 0.77 | PTGS2 (0.53) | ADORA1ADORA2AALDH1A1CYP1A2USP2 | |
| SCHEMBL5448840 | 0.77 | ADORA2B (0.52) | ADORA1ADORA2ACLK4 | |
| SCHEMBL2986078 | 0.76 | ADORA1 (0.56) | ADORA1ADORA2AALDH1A1CYP1A2USP2 | |
| SCHEMBL5451849 | 0.76 | ADORA1 (0.64) | ADORA1ADORA2AALDH1A1MEN1KMT2A | |
| SCHEMBL5448826 | 0.76 | ADORA1 (0.53) | ADORA1ADORA2AALDH1A1CYP1A2USP2 | |
| SCHEMBL5238815 | 0.71 | ADORA1 (0.59) | ADORA1ADORA2AALDH1A1USP2HSD17B10 | |
| SCHEMBL2971703 | 0.69 | ADORA1 (0.49) | ADORA1ADORA2AALDH1A1CYP1A2USP2 | |
| SCHEMBL3684480 | 0.69 | ADORA2A (1.00) | ADORA1ADORA2AALDH1A1CYP1A2USP2 | |
| SCHEMBL13202503 | 0.67 | MEN1 (0.46) | ADORA1ADORA2AALDH1A1CYP1A2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189717-B2 | Medicinal compositions promoting bowel movement | EISAI CO., LTD. (JP) | 2007-03-13 | — | — | US | disclosed |
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2007-03-08 | — | — | US | disclosed |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2006-11-30 | — | — | US | disclosed |
| EP-1510222-A2 | Medicinal compositions promoting bowel movement | Eisai Co. Ltd. (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1283056-B1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | EISAI CO LTD (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-09-11 | — | — | US | disclosed |
| EP-1283056-A1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | Eisai Co., Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2A 2/4885ALDH1A1 948/4885 |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | ADORA2A, ADORA1, ADORA3 | ADORA1 2/4885ADORA2A 1/4885ALDH1A1 612/4885 |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2A 2/4885ALDH1A1 938/4885 |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | ADORA2A, ADORA3, ADORA2B | ADORA1 4/4885ADORA2A 1/4885ALDH1A1 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.