SCHEMBL5459726

SCHEMBL5459726

COc1ccc(F)cc1NC(=O)Nc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
WNT3A P56704 1/20 0.51
DDB1 Q16531 1/20 0.49
CRBN Q96SW2 1/20 0.49
PGK1 P00558 1/20 0.48
ALK Q9UM73 5/20 0.46
CCNT1 O60563 1/20 0.46
CDK9 P50750 1/20 0.46
GALR2 O43603 1/20 0.46
GALR1 P47211 1/20 0.46
MAPT P10636 3/20 0.45
ALDH1A1 P00352 1/20 0.45
RET P07949 4/20 0.44
DGAT1 O75907 1/20 0.44
KDM4E B2RXH2 1/20 0.43
MTOR P42345 1/20 0.43
MEN1 O00255 1/20 0.43
TSHR P16473 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5462442 0.91 WNT3A (0.51) WNT3ADDB1CRBNPGK1MAPT
SCHEMBL5469390 0.91 WNT3A (0.53) WNT3ADDB1CRBNPGK1MAPT
SCHEMBL5460059 0.90 MAPT (0.50) WNT3ADDB1CRBNPGK1ALK
SCHEMBL5471069 0.89 ALDH1A1 (0.54) WNT3ADDB1CRBNPGK1MAPT
SCHEMBL5458287 0.88 MTOR (0.47) MAPTALDH1A1DGAT1KDM4EMTOR
SCHEMBL5470937 0.87 MAPT (0.53) ALKMAPTALDH1A1MEN1TSHR
SCHEMBL5473462 0.83 DGAT1 (0.53) WNT3ADDB1CRBNDGAT1
SCHEMBL5467414 0.83 CLK2 (0.51) MAPTALDH1A1MTORMEN1KMT2A
SCHEMBL5457902 0.82 WNT3A (0.53) WNT3ADDB1CRBNPGK1MAPT
SCHEMBL5465465 0.82 WNT3A (0.51) WNT3ADDB1CRBNPGK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070249620-A1 Urea Derivative SANKYO COMPANY, LIMITED (JP) 2007-10-25 US disclosed
EP-1764360-A1 UREA DERIVATIVE Sankyo Company, Limited (JP) 2007-03-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249620-A1 Urea Derivative UGP2, SLC14A1, DGAT1 WNT3A 3010/4885DDB1 1256/4885CRBN 2046/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.