Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464230 | 0.84 | TP53 (0.59) | MEN1KMT2APOLBSMN1; SMN2MAPT | |
| SCHEMBL5468423 | 0.83 | POLB (0.57) | MEN1KMT2APOLBKCNMA1SMN1; SMN2 | |
| SCHEMBL5460406 | 0.82 | KCNMA1 (0.62) | MEN1KMT2APOLBHDAC8HDAC1 | |
| SCHEMBL14363388 | 0.81 | ACLY (0.62) | ACLYMEN1KMT2APOLBHDAC8 | |
| SCHEMBL5463645 | 0.81 | HTT (0.51) | MEN1KMT2APOLBKCNMA1SMN1; SMN2 | |
| SCHEMBL330588 | 0.81 | ACLY (0.74) | ACLYMEN1KMT2APOLBHDAC8 | |
| SCHEMBL12368165 | 0.80 | MEN1 (0.65) | ACLYMEN1KMT2APOLBHDAC8 | |
| SCHEMBL5461743 | 0.80 | KDM4E (0.54) | MEN1KMT2APOLBKCNMA1SMN1; SMN2 | |
| SCHEMBL5463923 | 0.76 | KDM4E (0.48) | MEN1KMT2AKCNMA1SMN1; SMN2MAPT | |
| SCHEMBL5468424 | 0.76 | NPC1 (0.56) | MEN1KMT2APOLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1666469-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | ACLY 2561/4885MEN1 2892/4885KMT2A 2948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.