Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HRH2 | P25021 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5468405 | 0.86 | KDM4E (0.67) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5458309 | 0.84 | ME2 (0.56) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5453428 | 0.84 | KDM4E (0.52) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5456007 | 0.83 | HRH3 (0.47) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5455992 | 0.82 | HRH3 (0.53) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5464941 | 0.82 | ME2 (0.58) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5454869 | 0.82 | GFER (0.58) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5467837 | 0.82 | PANK3 (0.49) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5460606 | 0.80 | ALDH1A1 (0.53) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5455091 | 0.79 | HRH3 (0.51) | SIGMAR1TMEM97HRH3HTR1AHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | CNR2, GRIN2C, GRIN2B | SIGMAR1 129/4885TMEM97 486/4885HRH3 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.