Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.67 |
| ▸ | RAB9A | P51151 | 14/20 | 0.67 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405294 | 0.87 | RAB9A (0.63) | NPC1RAB9ATMPRSS2SMN1; SMN2MEN1 | |
| SCHEMBL5455943 | 0.84 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2HTTPKM | |
| SCHEMBL5458367 | 0.84 | RAB9A (0.69) | NPC1RAB9ASMN1; SMN2HTTPKM | |
| SCHEMBL1188455 | 0.83 | NPC1 (0.54) | NPC1RAB9ATMPRSS2SMN1; SMN2HTT | |
| SCHEMBL13654338 | 0.83 | NPC1 (0.54) | NPC1RAB9ATMPRSS2SMN1; SMN2HTT | |
| SCHEMBL1188162 | 0.82 | NPC1 (0.53) | NPC1RAB9ATMPRSS2SMN1; SMN2HTT | |
| SCHEMBL1187800 | 0.82 | NPC1 (0.53) | NPC1RAB9ATMPRSS2SMN1; SMN2HTT | |
| SCHEMBL1187798 | 0.82 | NPC1 (0.53) | NPC1RAB9ATMPRSS2SMN1; SMN2HTT | |
| SCHEMBL8161154 | 0.81 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2HTTPKM | |
| SCHEMBL1188566 | 0.81 | NPC1 (0.51) | NPC1RAB9ATMPRSS2PKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119534-A1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | 第一三共株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | NPC1 1089/4885RAB9A 1528/4885TMPRSS2 3127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.