Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 11/20 | 0.82 |
| ▸ | MEN1 | O00255 | 8/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.82 |
| ▸ | LMNA | P02545 | 6/20 | 0.72 |
| ▸ | HTT | P42858 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | DDX3X | O00571 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.55 |
| ▸ | IDH1 | O75874 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL2155975 | 0.96 | TRPV1 (0.93) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL20436795 | 0.88 | TRPV1 (0.78) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL18013179 | 0.86 | TRPV1 (0.76) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL4955544 | 0.86 | TRPV1 (0.75) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL18013184 | 0.86 | MEN1 (0.75) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL12305621 | 0.85 | TRPV1 (0.73) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL6371141 | 0.85 | TRPV1 (0.76) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL4554987 | 0.84 | MEN1 (0.82) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL27880343 | 0.83 | MEN1 (0.70) | TRPV1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL27861138 | 0.83 | MEN1 (0.82) | TRPV1MAPTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146548-A1 | AMIDE, ARYL SULFONAMIDE, ARYL UREA, AND a,b-DIKETONE DERIVED CARBOXYLESTERASE INHIBITORS, AND THEIR METHODS OF USE | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2008-06-19 | — | — | US | claimed |
| US-20050054691-A1 | Carboxylesterase inhibitors | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2005-03-10 | — | — | US | claimed |
| WO-2005021721-A2 | CARBOXYLESTERASE INHIBITORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2005-03-10 | — | — | WO | claimed |
| US-11339122-B2 | hTRPV1 chemical agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210171454-A1 | hTRPV1 CHEMICAL AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-06-10 | — | — | US | disclosed |
| US-20180215705-A1 | hTRPV1 CHEMICAL AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-08-02 | — | — | US | disclosed |
| US-20180215705-A1 | hTRPV1 CHEMICAL AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-08-02 | — | — | US | disclosed |
| WO-2016127085-A1 | hTRPV1 CHEMICAL AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-08-11 | — | — | WO | disclosed |
| EP-2170834-B1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AS INHIBITORS OF PROTEIN KINASES | ABBVIE INC (US) | 2014-01-08 | — | — | EP | disclosed |
| US-8110572-B2 | Inhibitors of protein kinases | ABBOTT LABORATORIES (US) | 2012-02-07 | — | — | US | disclosed |
| EP-2170834-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AS INHIBITORS OF PROTEIN KINASES | Abbott Laboratories (US) | 2010-04-07 | — | — | EP | disclosed |
| US-20090054430-A1 | Inhibitors of Protein Kinases | ABBOTT LABORATORIES (US) | 2009-02-26 | — | — | US | disclosed |
| WO-2009012312-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054691-A1 | Carboxylesterase inhibitors | CES1, CES2, BCHE | TRPV1 4218/4885MAPT 3726/4885MEN1 4615/4885 |
| US-20080146548-A1 | AMIDE, ARYL SULFONAMIDE, ARYL UREA, AND a,b-DIKETONE DERIVED CARBOXYLESTERASE INHIBITORS, AND THEIR METHODS OF USE | CES1, BCHE, CES2 | TRPV1 4194/4885MAPT 4046/4885MEN1 4755/4885 |
| US-20180215705-A1 | hTRPV1 CHEMICAL AGENTS | TRPV1, TRPA1, TRPV4 | TRPV1 1/4885MAPT 4496/4885MEN1 4341/4885 |
| US-20210171454-A1 | hTRPV1 CHEMICAL AGENTS | TRPV1, TRPA1, TRPV4 | TRPV1 1/4885MAPT 4483/4885MEN1 4488/4885 |
| US-20090054430-A1 | Inhibitors of Protein Kinases | AURKC, AURKB, PLK1 | TRPV1 4714/4885MAPT 654/4885MEN1 950/4885 |
| US-11339122-B2 | hTRPV1 chemical agents | TRPV1, TRPA1, TRPV4 | TRPV1 1/4885MAPT 4496/4885MEN1 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.