Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463157 | 1.00 | PTPN11 (0.49) | PTPN11NPY5RLMNASMN1; SMN2KDM4E | |
| SCHEMBL5463162 | 1.00 | PTPN11 (0.49) | PTPN11NPY5RLMNASMN1; SMN2KDM4E | |
| SCHEMBL5459846 | 0.85 | MCHR1 (0.52) | NPY5RCDK2CDC7DAPK3JAK2 | |
| SCHEMBL13793907 | 0.83 | APP (0.52) | PTPN11NPY5RLMNASMN1; SMN2KDM4E | |
| SCHEMBL13793576 | 0.83 | APP (0.52) | PTPN11NPY5RLMNASMN1; SMN2KDM4E | |
| SCHEMBL5943477 | 0.81 | KDM4E (0.74) | LMNASMN1; SMN2KDM4EHTTALDH1A1 | |
| SCHEMBL5528796 | 0.77 | MCHR1 (0.56) | NPY5RAPPBCHEACHE | |
| SCHEMBL5528801 | 0.77 | MCHR1 (0.56) | NPY5RAPPBCHEACHE | |
| SCHEMBL13793565 | 0.75 | CYP1A2 (0.56) | NPY5RLMNASMN1; SMN2KDM4EPAK4 | |
| SCHEMBL13793109 | 0.75 | APP (0.52) | PTPN11NPY5RHSD17B10TSHRAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185119-A1 | Therapeutic agents II | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185119-A1 | Therapeutic agents II | HTT, ACHE, GPR119 | PTPN11 4596/4885NPY5R 2575/4885LMNA 3935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.