Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447893 | 0.84 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10GAATSHR | |
| SCHEMBL27681017 | 0.80 | RBP4 (0.61) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL5457627 | 0.76 | ALDH1A1 (0.40) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL24656055 | 0.72 | KHK (0.49) | KDM4EKMT2AKHKPIK3CAMTOR | |
| SCHEMBL15107946 | 0.72 | SORD (0.45) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL13033928 | 0.72 | CASP1 (0.47) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14428506 | 0.69 | MAP4K4 (0.43) | KDM4EALDH1A1KMT2AKHKPOLB | |
| SCHEMBL18781075 | 0.69 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL1688142 | 0.68 | KHK (0.50) | ALDH1A1KMT2AKHKPIK3CAMTOR | |
| SCHEMBL1839601 | 0.67 | TYMP (0.45) | KDM4EALDH1A1KMT2AKHKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ARAF, BRAF, RAF1 | KDM4E 521/4885ALDH1A1 309/4885HSD17B10 4741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.