Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456514 | 0.95 | ALDH1A1 (0.54) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL5463620 | 0.90 | CHRNB2 (0.65) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL28987798 | 0.88 | CHRNB2 (0.58) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL28674730 | 0.85 | CHRNB2 (0.59) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL5409935 | 0.83 | CHRNB2 (0.60) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL5459223 | 0.83 | ALDH1A1 (0.50) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL17154322 | 0.83 | KCNH2 (0.64) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL31091563 | 0.82 | CHRNB2 (0.59) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL19734471 | 0.81 | CHRNB2 (0.55) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL8573983 | 0.81 | DRD2 (0.55) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | claimed |
| CN-102370638-A | Application of 3,3'-diindolylmethane and 3,3'-diindolylmethane derivatives in preparation of drugs for treating liver diseases | NANJING UNIVERSITY | 2012-03-14 | — | — | CN | claimed |
| US-20040058897-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2004-03-25 | — | — | US | claimed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | claimed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| CN-108245509-A | The application of DIM and its derivative in preparing prevention chemotherapy and causing damage medicine | 南京大学 | 2018-07-06 | — | — | CN | disclosed |
| CN-105030766-A | Indole-3-carbinol, di-indolyl methane and application of derivatives of indole-3-carbinol and di-indolyl methane to medicine for treating allergic pharyngitis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-11-11 | — | — | CN | disclosed |
| CN-105012297-A | Use of indole-3-carbinol, bis-indolymethane and derivatives thereof in drugs for treatment on contact dermatitis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-11-04 | — | — | CN | disclosed |
| CN-104997772-A | Application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-10-28 | — | — | CN | disclosed |
| CN-104940194-A | Application of benzpyrole-3-methyl alcohol, diindolylmethane and ramification thereof used for medicine for treating refractory periodontitis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-09-30 | — | — | CN | disclosed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | disclosed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |