Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882102 | 0.88 | HTT (0.55) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL7373159 | 0.87 | DRD2 (0.52) | ALDH1A1HTTTSHRKDM4EPOLB | |
| Water SCHEMBL11540986 | 0.86 | HTT (0.53) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL8573983 | 0.86 | DRD2 (0.55) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL5463620 | 0.86 | CHRNB2 (0.65) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL5465366 | 0.83 | CHRNB2 (0.54) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL5456514 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL22132140 | 0.81 | CHRNB2 (0.47) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL14193990 | 0.81 | CHRNB2 (0.64) | ALDH1A1HTTTSHRKDM4EPOLB | |
| SCHEMBL3743077 | 0.80 | KDM4E (0.67) | ALDH1A1TSHRKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | claimed |
| CN-102370638-A | Application of 3,3'-diindolylmethane and 3,3'-diindolylmethane derivatives in preparation of drugs for treating liver diseases | NANJING UNIVERSITY | 2012-03-14 | — | — | CN | claimed |
| US-20040058897-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2004-03-25 | — | — | US | claimed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | claimed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| CN-108245509-A | The application of DIM and its derivative in preparing prevention chemotherapy and causing damage medicine | 南京大学 | 2018-07-06 | — | — | CN | disclosed |
| CN-105030766-A | Indole-3-carbinol, di-indolyl methane and application of derivatives of indole-3-carbinol and di-indolyl methane to medicine for treating allergic pharyngitis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-11-11 | — | — | CN | disclosed |
| CN-105012297-A | Use of indole-3-carbinol, bis-indolymethane and derivatives thereof in drugs for treatment on contact dermatitis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-11-04 | — | — | CN | disclosed |
| CN-104997772-A | Application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-10-28 | — | — | CN | disclosed |
| CN-104940194-A | Application of benzpyrole-3-methyl alcohol, diindolylmethane and ramification thereof used for medicine for treating refractory periodontitis | ANHUI SIZHENG MEDICAL TECHNOLOGY CO LTD | 2015-09-30 | — | — | CN | disclosed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | disclosed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |