Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.65 |
| ▸ | GRM5 | P41594 | 8/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458325 | 0.87 | NAMPT (0.64) | NAMPTGRM5GRM1PDK4NPC1 | |
| SCHEMBL5463378 | 0.84 | NPC1 (0.58) | NAMPTNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL22325022 | 0.81 | NAMPT (0.71) | NAMPTGRM5GRM1PDK4NPC1 | |
| SCHEMBL5453589 | 0.80 | NAMPT (0.57) | NAMPTGRM5GRM1RAB9ASMN1; SMN2 | |
| SCHEMBL5473484 | 0.80 | NAMPT (0.62) | NAMPTGRM5GRM1PDK4ALDH1A1 | |
| SCHEMBL5457840 | 0.80 | NAMPT (0.62) | NAMPTNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL31488872 | 0.79 | NAMPT (0.75) | NAMPTNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL12479794 | 0.79 | NAMPT (0.55) | NAMPTGRM5GRM1PDK4CDK7 | |
| SCHEMBL3707364 | 0.79 | NAMPT (1.00) | NAMPT | |
| SCHEMBL31488923 | 0.79 | NAMPT (0.68) | NAMPTGRM5GRM1PDK4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | NAMPT 324/4885GRM5 2380/4885GRM1 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.