Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 5/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.56 |
| ▸ | ACP1 | P24666 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5466747 | 1.00 | ENPP2 (0.58) | ENPP2PTPN1ACP1NPC1NLRP3 | |
| SCHEMBL5461249 | 0.87 | PTPN1 (0.59) | ENPP2PTPN1ACP1NLRP3PTPN2 | |
| SCHEMBL5463880 | 0.87 | PTPN1 (0.60) | ENPP2PTPN1ACP1PTPN2MEN1 | |
| SCHEMBL5461246 | 0.87 | PTPN1 (0.59) | ENPP2PTPN1ACP1NLRP3PTPN2 | |
| SCHEMBL5463879 | 0.87 | PTPN1 (0.60) | ENPP2PTPN1ACP1PTPN2MEN1 | |
| SCHEMBL5462391 | 0.87 | NLRP3 (0.62) | ENPP2PTPN1ACP1NPC1NLRP3 | |
| SCHEMBL5462396 | 0.87 | NLRP3 (0.62) | ENPP2PTPN1ACP1NPC1NLRP3 | |
| SCHEMBL5460593 | 0.86 | PTPN1 (0.54) | ENPP2PTPN1ACP1PTPN2MEN1 | |
| SCHEMBL5460594 | 0.86 | PTPN1 (0.54) | ENPP2PTPN1ACP1PTPN2MEN1 | |
| SCHEMBL5462482 | 0.85 | CFTR (0.62) | ENPP2PTPN1ACP1NLRP3PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1666469-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | ENPP2 1911/4885PTPN1 3264/4885ACP1 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.