Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.65 |
| ▸ | SMYD2 | Q9NRG4 | 4/20 | 0.58 |
| ▸ | TACR2 | P21452 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18502024 | 0.89 | SMYD2 (0.59) | OPRK1OPRL1SMYD2TACR2CHRNB2 | |
| SCHEMBL14430712 | 0.82 | SLC6A2 (0.69) | SMYD2ACHEHTR3AKDM4EALDH1A1 | |
| SCHEMBL7692996 | 0.82 | HTR4 (0.57) | SMYD2KDM4EALDH1A1LMNATP53 | |
| SCHEMBL11275539 | 0.82 | HTR4 (0.57) | SMYD2KDM4EALDH1A1LMNATP53 | |
| SCHEMBL5474202 | 0.81 | ALDH1A1 (0.71) | SMYD2KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL10652624 | 0.81 | NAMPT (0.50) | SMYD2ACHETP53POLB | |
| SCHEMBL13164073 | 0.80 | SMYD2 (0.62) | SMYD2 | |
| SCHEMBL11276343 | 0.80 | KDM4E (0.56) | SMYD2KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL5477836 | 0.80 | OPRL1 (0.66) | OPRL1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL1384427 | 0.79 | ALDH1A1 (0.72) | SMYD2KDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | GRIN2C, TPH2, HTR5A | OPRK1 54/4885OPRL1 11/4885SMYD2 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.