Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5471833 | 0.91 | SOS1 (0.55) | TRPC5ALDH1A1HTTPOLBKMT2A | |
| SCHEMBL5471566 | 0.87 | DRD4 (0.56) | ALDH1A1HTTPOLBKMT2ASOS1 | |
| SCHEMBL3498573 | 0.79 | BRD4 (0.47) | TRPC5NCF1CSF1RBRD4NTRK1 | |
| SCHEMBL23295565 | 0.74 | HTT (0.69) | TRPC5ALDH1A1HTTPOLBKMT2A | |
| SCHEMBL6200777 | 0.74 | SIGMAR1 (0.71) | ALDH1A1HTTPOLBKMT2ANCF1 | |
| SCHEMBL102338 | 0.74 | SIGMAR1 (0.71) | ALDH1A1HTTPOLBKMT2ANCF1 | |
| SCHEMBL5434228 | 0.73 | ALDH1A1 (0.57) | ALDH1A1HTTPOLBKMT2ASOS1 | |
| SCHEMBL939417 | 0.73 | TNF (0.79) | ALDH1A1HTTPOLBKMT2ASOS1 | |
| SCHEMBL948372 | 0.72 | SIGMAR1 (0.68) | ALDH1A1HTTPOLBKMT2ANCF1 | |
| SCHEMBL18065638 | 0.72 | SIGMAR1 (0.68) | ALDH1A1HTTPOLBKMT2ANCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663988-B1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-04-16 | — | — | EP | claimed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | claimed |
| EP-1663988-B1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-04-16 | — | — | EP | disclosed |
| EP-1663988-B1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-04-16 | — | — | EP | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| EP-1663988-A1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028448-A1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | TIE1, KDR, FLT1 | TRPC5 3283/4885ALDH1A1 745/4885HTT 3647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.