Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 7/20 | 0.80 |
| ▸ | LMNA | P02545 | 7/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.80 |
| ▸ | ATM | Q13315 | 3/20 | 0.80 |
| ▸ | PGR | P06401 | 3/20 | 0.80 |
| ▸ | AR | P10275 | 3/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.80 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.63 |
| ▸ | SHBG | P04278 | 2/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | HTR2B | P41595 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547938 | 0.97 | LMNA (0.73) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL1315380 | 0.97 | LMNA (0.73) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL17419453 | 0.97 | LMNA (0.73) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL17419466 | 0.97 | LMNA (0.73) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL548012 | 0.97 | LMNA (0.73) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL4333126 | 0.93 | LMNA (0.75) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL40564 | 0.93 | LMNA (0.75) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL11102416 | 0.93 | LMNA (0.75) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL9404736 | 0.90 | LMNA (0.77) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL7633202 | 0.90 | LMNA (0.73) | LMNAESR1SMN1; SMN2ADORA3ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110565-B2 | Of the ACE inhibitor ramipril; controlling the melting point by mixing with the free acid with the ramipril ethyl or methyl ester prodrug and a pressure sensitive adhesive carrier; improved pharmacokinetics; sustained release | NOVEN PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-8025898-B2 | Of the ACE inhibitor ramipril by mixing with the ramipril (m)ethyl ester prodrug and a pressure sensitive adhesive carrier; improved pharmacokinetics; sustained release | NOVEN PHARMACEUTICALS, INC. (US) | 2011-09-27 | — | — | US | disclosed |
| US-20080167280-A1 | Enhanced drug delivery in transdermal systems | NOVEN PHARMACEUTICALS, INC. | 2008-07-10 | — | — | US | disclosed |
| US-20080167365-A1 | Enhanced drug delivery in transdermal systems | NOVEN PHARMACEUTICALS, INC. | 2008-07-10 | — | — | US | disclosed |