Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24290490 | 0.83 | NCF1 (0.48) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL5471056 | 0.80 | MAPT (0.65) | ALDH1A1HTTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL546487 | 0.76 | HRH3 (0.59) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL30059176 | 0.76 | HRH3 (0.59) | NCF1ALDH1A1HTTKDM4EHPGD | |
| Ammonia Solution, Strong SCHEMBL548075 | 0.74 | HRH3 (0.58) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL6200777 | 0.73 | SIGMAR1 (0.71) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL102338 | 0.73 | SIGMAR1 (0.71) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL15722561 | 0.73 | MAPT (0.65) | ALDH1A1HTTKDM4EPIK3CBNPC1 | |
| SCHEMBL948372 | 0.72 | SIGMAR1 (0.68) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL18065638 | 0.72 | SIGMAR1 (0.68) | NCF1ALDH1A1HTTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663988-B1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-04-16 | — | — | EP | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | TIE1, KDR, FLT1 | NCF1 3032/4885ALDH1A1 745/4885HTT 3647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.