Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | CLPP | Q16740 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945249 | 0.84 | HTT (0.54) | RAB9AMAPTTP53HTTNPC1 | |
| SCHEMBL5786742 | 0.82 | ALDH1A1 (0.47) | RAB9AMAPTNPC1MAPK1CYP3A4 | |
| SCHEMBL5465739 | 0.82 | JAK2 (0.45) | JAK2TYK2CLPPRAB9AMAPT | |
| SCHEMBL14419354 | 0.79 | NPC1 (0.35) | RAB9AMAPTTP53HTTNPC1 | |
| SCHEMBL1922880 | 0.78 | JAK2 (0.49) | JAK2TYK2CLPPRAB9AMAPT | |
| SCHEMBL29966096 | 0.74 | KDM4E (0.54) | JAK2TYK2RAB9AMAPTFLT1 | |
| SCHEMBL2468448 | 0.74 | KDM4E (0.54) | JAK2TYK2RAB9AMAPTFLT1 | |
| SCHEMBL7091405 | 0.73 | RAB9A (0.65) | JAK2TYK2RAB9AMAPTFLT1 | |
| SCHEMBL473972 | 0.72 | ALDH1A1 (0.65) | JAK2TYK2RAB9AMAPTFLT1 | |
| SCHEMBL295414 | 0.72 | SMN1; SMN2 (0.57) | JAK2TYK2RAB9AMAPTFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070224636-A1 | Pyrrolo[1,2b]pyridazine compounds and their uses | PFIZER INC | 2007-09-27 | — | — | US | disclosed |
| US-20070224636-A1 | Pyrrolo[1,2b]pyridazine compounds and their uses | PFIZER INC | 2007-09-27 | — | — | US | disclosed |
| US-7056920-B2 | Pyrrolo[1,2-B]pyridazine compounds and their uses | PFIZER INC (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1613631-A1 | PYRROLO 1,2-B PYRIDAZINE COMPOUNDS AND THEIR USES | Pharmacia & Upjohn Company LLC (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087709-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-10-14 | — | — | WO | disclosed |
| US-20040204415-A1 | Pyrrolo[1,2-B]pyridazine compounds and their uses | PFIZER INC | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204415-A1 | Pyrrolo[1,2-B]pyridazine compounds and their uses | CRHR1, CRHR2, CRH | JAK2 1347/4885TYK2 3379/4885CLPP 3942/4885 |
| US-20070224636-A1 | Pyrrolo[1,2b]pyridazine compounds and their uses | CRHR1, CRHR2, CRH | JAK2 1295/4885TYK2 3157/4885CLPP 3491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.