Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | NPC1 | O15118 | 7/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.65 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480697 | 0.90 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5479816 | 0.87 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5485409 | 0.86 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5472719 | 0.85 | PRMT5 (0.54) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5479157 | 0.82 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5479149 | 0.82 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5475685 | 0.81 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5478987 | 0.81 | RAB9A (0.64) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL1061025 | 0.81 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL5476959 | 0.80 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275995-A1 | Thiobenzimidazole derivatives | TEIJIN PHARMA LIMITED | 2007-11-29 | — | — | US | disclosed |
| US-7268145-B2 | Thiobenzimidazole derivatives | TEIJIN PHARMA LIMITED (JP) | 2007-09-11 | — | — | US | disclosed |
| US-20060040976-A1 | Thiobenzimidazole derivatives | TEIJIN LIMITED | 2006-02-23 | — | — | US | disclosed |
| US-20050267148-A1 | Benzimidazole derivative | TEIJIN LIMITED | 2005-12-01 | — | — | US | disclosed |
| EP-1097926-A1 | THIOBENZIMIDAZOLE DERIVATIVES | TEIJIN LIMITED (JP) | 2001-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275995-A1 | Thiobenzimidazole derivatives | CMA1, SERPINB1, TMPRSS15 | RAB9A 2783/4885NPC1 525/4885SMN1; SMN2 2109/4885 |
| US-20060040976-A1 | Thiobenzimidazole derivatives | CMA1, SERPINB1, TMPRSS15 | RAB9A 2783/4885NPC1 525/4885SMN1; SMN2 2109/4885 |
| US-20050267148-A1 | Benzimidazole derivative | CMA1, SERPINB1, TPSAB1 | RAB9A 3040/4885NPC1 407/4885SMN1; SMN2 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.