Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873072 | 0.89 | MAPT (0.68) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL30924933 | 0.87 | MAPT (0.63) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| Iodide SCHEMBL11813030 | 0.86 | MAPT (0.65) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL10974237 | 0.85 | INSR (0.46) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL10974234 | 0.85 | INSR (0.46) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| Perchlorate SCHEMBL10998853 | 0.85 | MAPT (0.58) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL10949400 | 0.77 | MAPT (0.48) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL10973508 | 0.76 | TSHR (0.40) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL10973513 | 0.76 | TSHR (0.40) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3766310 | 0.76 | ADRB2 (0.71) | ALDH1A1MAPTMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166715-B2 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | APPLERA CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
| US-20050009058-A1 | As quencher in reporter-quencher energy-transfer dye pair for nucleic acid hybridization assays; hairpin motif | APPLERA CORPORATION (US) | 2005-01-13 | — | — | US | disclosed |
| US-6750024-B2 | USEFUL AS QUENCHERS IN A REPORTER-QUENCHER ENERGY-TRANSFER DYE PAIR | APPLERA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | APPLERA CORPORATION (US) | 2003-11-06 | — | — | US | disclosed |
| US-6541618-B1 | Detecting hybrids | APPLERA CORPORATION | 2003-04-01 | — | — | US | disclosed |
| US-6348596-B1 | NUCLEIC ACID HYBRIDIZATION ASSAYS; DNA SEQUENCE DETERMINATION | PE CORPORATION (NY) | 2002-02-19 | — | — | US | disclosed |
| EP-1049744-B1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE CORP NY (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-1049744-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE Corporation (NY) (US) | 2000-11-08 | — | — | EP | disclosed |
| US-6080868-A | AS A QUENCHER IN A REPORTER-QUENCHER ENERGY-TRANSFER DYE PAIR FOR NUCLEIC ACID HYBRIDIZATION ASSAYS | THE PERKIN-ELMER CORPORATION (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1999037717-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | THE PERKIN-ELMER CORPORATION (US) | 1999-07-29 | — | — | WO | disclosed |
| EP-0605655-B1 | DIMERS OF UNSYMMETRICAL CYANINE DYES | MOLECULAR PROBES INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5582977-A | NUCLEIC ACIDS STAINING | MOLECULAR PROBES, INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0605655-A1 | DIMERS OF UNSYMMETRICAL CYANINE DYES. | MOLECULAR PROBES INC (US) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993006482-A1 | DIMERS OF UNSYMMETRICAL CYANINE DYES | MOLECULAR PROBES, INC. (US) | 1993-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | NSUN3, NSUN2, NCL | ALDH1A1 2958/4885MAPT 4395/4885MEN1 3651/4885 |
| US-20050009058-A1 | As quencher in reporter-quencher energy-transfer dye pair for nucleic acid hybridization assays; hairpin motif | NSUN3, SRRT, RNGTT | ALDH1A1 3416/4885MAPT 4443/4885MEN1 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.