Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 6/20 | 0.49 |
| ▸ | TERT | O14746 | 3/20 | 0.49 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14388990 | 0.87 | RAD52 (0.75) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL3952873 | 0.86 | RAD52 (0.78) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL14388988 | 0.86 | TERT (0.57) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL18655357 | 0.79 | MAOA (0.49) | KMT2ANPC1RAB9ASCN9A | |
| SCHEMBL31087715 | 0.74 | RAD52 (1.00) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL4725486 | 0.74 | RAD52 (1.00) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL10310536 | 0.71 | TOP2A (0.57) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL530085 | 0.70 | KMT2A (0.50) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL18631798 | 0.70 | POLB (0.49) | RAD52POLBKMT2ANPC1SLC2A1 | |
| SCHEMBL18655358 | 0.70 | MAOA (0.43) | KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854509-A2 | Methods and compositions for restoring conformational stability of a protein of the p53 family | Pfizer Products Inc. (US) | 2007-11-14 | — | — | EP | claimed |
| EP-1137418-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | claimed |
| WO-2000032175-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | PFIZER PRODUCTS INC. (US) | 2000-06-08 | — | — | WO | claimed |
| EP-1854509-A2 | Methods and compositions for restoring conformational stability of a protein of the p53 family | Pfizer Products Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1854509-A2 | Methods and compositions for restoring conformational stability of a protein of the p53 family | Pfizer Products Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1137418-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000032175-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | PFIZER PRODUCTS INC. (US) | 2000-06-08 | — | — | WO | disclosed |