Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.63 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.63 |
| ▸ | TGM2 | P21980 | 1/20 | 0.60 |
| ▸ | CTSL | P07711 | 6/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | ECE1 | P42892 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15804479 | 0.90 | SIRT2 (0.63) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL2963543 | 0.89 | SIRT2 (0.76) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL7689520 | 0.89 | SIRT2 (0.76) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL21357647 | 0.89 | SIRT2 (0.76) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL4787188 | 0.89 | SIRT2 (0.76) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL17279329 | 0.88 | SIRT2 (0.74) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL11308449 | 0.88 | SIRT2 (0.74) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL17694104 | 0.88 | SIRT2 (0.74) | SIRT2SIRT1TGM2CTSLCTSS | |
| SCHEMBL2487005 | 0.88 | CTSL (0.65) | CTSLCTSSCTSBCASP1 | |
| SCHEMBL1701581 | 0.88 | CTSL (0.65) | CTSLCTSSCTSBCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070224263-A1 | Aminoalkylphosphonates and related compounds as Edg receptor agonists | DOHERTY GEORGE A | 2007-09-27 | — | — | US | disclosed |
| US-20060089334-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | MERCK & CO., INC. | 2006-04-27 | — | — | US | disclosed |
| US-20050107345-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | DOHERTY GEORGE A (US) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089334-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | ADGRF1, EDNRA, ADGRE5 | SIRT2 4582/4885SIRT1 4525/4885TGM2 2990/4885 |
| US-20050107345-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | EDNRA, ADGRE5, ADGRF1 | SIRT2 4385/4885SIRT1 4694/4885TGM2 2701/4885 |
| US-20070224263-A1 | Aminoalkylphosphonates and related compounds as Edg receptor agonists | ADGRE5, EDNRA, ADGRF1 | SIRT2 4118/4885SIRT1 4706/4885TGM2 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.