Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.66 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.61 |
| ▸ | CCR3 | P51677 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473968 | 0.93 | SCN9A (0.68) | NAMPTCD274CCR3MAPTRECQL | |
| SCHEMBL19878395 | 0.87 | DRD2 (0.60) | NAMPTMAPTRECQLCYP1A2CYP2D6 | |
| SCHEMBL19891111 | 0.85 | DRD2 (0.61) | NAMPTMAPTRECQLCYP1A2CYP2D6 | |
| SCHEMBL5481802 | 0.85 | SMYD2 (0.63) | NAMPTSMYD2SCN9APOLBDRD3 | |
| SCHEMBL16151552 | 0.85 | DRD2 (0.61) | NAMPTCCR3MAPTRECQLCYP1A2 | |
| SCHEMBL5481507 | 0.83 | SCN9A (0.68) | NAMPTSMYD2SCN9ALMNAL3MBTL1 | |
| SCHEMBL18507101 | 0.83 | L3MBTL3 (0.61) | NAMPTCD274CCR3SCN9ADRD3 | |
| SCHEMBL13211930 | 0.82 | NPSR1 (0.79) | NAMPTMAPTRECQLCYP1A2CYP2D6 | |
| SCHEMBL3112471 | 0.82 | MAPT (0.60) | NAMPTMAPTRECQLSMYD2CYP1A2 | |
| SCHEMBL14005954 | 0.82 | DRD3 (0.63) | NAMPTCD274CCR3SMYD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | GRIN2C, TPH2, HTR5A | NAMPT 3438/4885CD274 3411/4885CCR3 4414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.