Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17339154 | 0.74 | TDP1 (0.46) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL28967249 | 0.68 | TDP1 (0.49) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| Benzyl Benzoate SCHEMBL27990934 | 0.67 | KMT2A (0.92) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL21538018 | 0.67 | TDP1 (0.66) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL14768871 | 0.67 | TDP1 (0.66) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| Benzyl Benzoate SCHEMBL901058 | 0.66 | KMT2A (1.00) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| Benzyl Benzoate SCHEMBL3038 | 0.66 | KMT2A (1.00) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| Benzyl Benzoate SCHEMBL8010992 | 0.66 | KMT2A (1.00) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL312287 | 0.66 | KMT2A (0.92) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL50441 | 0.66 | ALDH1A1 (0.89) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536541-B | Process for the preparation of ramipril | 赛诺菲-安万特德国有限公司 | 2021-01-08 | — | — | CN | disclosed |
| US-10112973-B2 | Process for the preparation of ramipril | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2018-10-30 | — | — | US | disclosed |
| EP-3154940-B1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2018-04-18 | — | — | EP | disclosed |
| US-20170158733-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2017-06-08 | — | — | US | disclosed |
| EP-3154940-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | Sanofi-Aventis Deutschland GmbH (DE) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015189108-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2015-12-17 | — | — | WO | disclosed |
| US-20070232680-A1 | PREPARATION OF RAMIPRIL AND STABLE PHARMACEUTICAL COMPOSITIONS | DR. REDDY'S LABORATORIES, INC. | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10112973-B2 | Process for the preparation of ramipril | CYP2S1, CYP3A5, CYP4B1 | TDP1 3674/4885KMT2A 2170/4885SLC6A2 634/4885 |
| US-20070232680-A1 | PREPARATION OF RAMIPRIL AND STABLE PHARMACEUTICAL COMPOSITIONS | REN, ADRA2A, CYP3A5 | TDP1 3284/4885KMT2A 2130/4885SLC6A2 294/4885 |
| US-20170158733-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | CYP2S1, CYP3A5, CYP4B1 | TDP1 3674/4885KMT2A 2170/4885SLC6A2 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.